Heterogeneous Gene Data for Classifying Tumors
نویسنده
چکیده
When classifying tumors using gene expression data, mining tasks commonly make use of only a single data set. However, classification models based on patterns extracted from a single data set are often not indicative of an entire population and heterogeneous samples subsequently applied to these models may not fit, leading to performance degradation. In short, it is not possible to guarantee that mining results based on a single gene expression data set will be reliable or robust (Miller et al., 2002). This problem can be addressed using classification algorithms capable of handling multiple, heterogeneous gene expression data sets. Apart from improving mining performance, the use of such algorithms would make mining results less sensitive to the variations of different microarray platforms and to experimental conditions embedded in heterogeneous gene expression data sets.
منابع مشابه
Hypermethylation of E-Cadherin and Estro-gen Receptor- Gene Promoter and Its Association with Clinicopathological Features of Breast Cancer in Iranian Patients
Background: Aberrant methylation of cytosine-guanine dinucleotide islands leads to inactivation of tumor suppressor genes in breast cancer. Tumor suppressor genes are unmethylated in normal tissue and often become hypermethylated during tumor formation, leading to gene silencing. We investigated the association between E-cadherin (CDH1) and estrogen receptor-α (ESRα) gene promoter methylation a...
متن کاملMolecular and genetic aspects of odontogenic tumors: a review
Odontogenic tumors contain a heterogeneous collection of lesions that are categorized from hamartomas to benign and malignant neoplasms of inconstant aggressiveness. Odontogenic tumors are usually extraordinary with assessed frequency of short of 0.5 cases/100,000 population for every year. The lesions such as odontogenic tumors are inferred from the components of the tooth-structuring contrapt...
متن کاملThe Association of 4G/5G Polymorphism of PAI-1-675 Gene with Clinicopathologic Features of Thyroid Tumors in Iranian Azeri Turkish Patients
Background: Due to the lack of information about the role of 4G/5G polymorphism of PAI-1 Gene in susceptibility to thyroid tumors, this study was performed to evaluate the potential effects of this polymorphism on clinicopathologic features of thyroid tumors in Iranian Azeri Turkish patients. Methods:In this case-control study, 90 patients with thyroid tumors ...
متن کاملExpression profile of ZFX isoform3/variant 5 in gastric cancer tissues and its association with tumor size
Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...
متن کاملDetection of Survivin Gene Expression in Formalin-Fixed Paraffin-Embedded Tissues of Human Osteosarcoma: Its Potential Usefulness in Diagnosis and Prognosis of Bone Tumors
Osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. Diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. Survivin, an inhibitor of apoptosis (IAP), is unique for its expression in human tumors ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015